John Henry Tilden publica en 1921 su obra central Impaired Health: Its Cause And Cure Vol, donde expone los principios y fundamentos de la toxemia como origen de los problemas de salud que afligen a la humanidad. Tilden sistematiza un concepto nuclear de la epistemología, metodología, tecnología y praxiología de Naturopatía recogiendo la tradición egipcia, grecolatina y oriental donde también singularizan los problemas derivados del concepto de toxemia que Tilden desarrolla en su obra.

La obra está divide en los siguientes capítulos:

Man A Digestive Apparatus

Bacteria Necessary

The Sterilized Are Sick And Die

Fermentation And Decomposition Defined

Fermentation And Decomposition Defined. Continued

The Philosophy Of Toxin Poisoning

The Limitation Of Putrefactive Fermentation

Why Contagious And Infectious Diseases Have Declined

Chapter I. The Science And Art Of Medicine

The Science And Art Of Medicine. Continued

Chapter II. Disease – What Is It?

Chapter III. The Study Of Medicine

I. Pathology

Crises

Etiology

1. Enviromnent In Its Relationship To Health And Disease

Cell-Life

2. Physical Agents.

   . Air

   . Altitude

   . Altitude. Continued

   . Heat

   . Heat. Continued

   . Cold

   . Light

   . Sound

   . Sound. Continued

   . Electricity

   . Electricity. Continued

3. Chemical Agents. Caustics

   . Toxin (Poison)

   . Alimentary Poison

   . Beverages

   . Lead

   . Poisons In The Air

4. Animate Agents. History Of Infection

History Of Infection. Part 2

History Of Infection. Part 3

History Of Infection. Part 4

History Of Infection. Part 5

A Reasonable Explanation Of Germ Action

A Reasonable Explanation Of Germ Action. Continued

5. Nervous Reactions

Nervous Reactions. Part 2

Nervous Reactions. Part 3

Nervous Reactions. Part 4

Mental Or Physical Reactions

Influence Of Sex In Bringing About Shock In The Human Species

6. Nutrition

   . Necessary To Cell-Buildin

   . Functions Of Nutrition

   . Fasting

   . Liquefying Food

   . Liquefying Food. Part 2

   . Liquefying Food. Part 3

   . Chlorosis

   . Emotional Disturbances

   . Urea

   . Disturbed Nutrition

   . Auto-Intoxication

   . Toxins In The Tissues Of The Body In Standard Healt

   . The Toxicity Of Urine

   . Overworked Organs

   . Auto-Intoxication From Enervated Skin, Lungs, And Kidneys

   . Lactic Acid Poisoning

7. Diatheses

Diatheses. Part 2

Diatheses. Part 3Scrofulous–Adenitis–Or Tubercular Diathesis

Characteristics Of The Scrofulous Subject

Gouty Diathesis

8. Heredity

Heredity. Continued

Cause Of Crime

Degeneration Is Not Transmissible

Why Criminals Do Not Reform

The Possibilities Of A Child

9. Pathology Of The Fetus

Pathology Of The Fetus. Part 2

Pathology Of The Fetus. Part 3

Benevolent Assimilation–A Conservative Force

Influence Of Chronic Intoxications

Saturnism (Lead Poisoning)

Hereditary Syphilis

Hereditary Syphilis. Continued

10. Inflammation

Inflammation. Continued

The Wound And Natures Mechanism

Inflammations Of Mucous Membranes

11. Septicemia And Pyemia

Bacteriemia

Septicemia

Sclerosis

Reparation Of Lesions

Intoxications Of All Kinds

Where Sclerosis Gets Its Origin

Arteriosclerosis

Histology. Tissue

Teratology

Cancer

Histogenetic Tumors

Adenoma

When Does A Cancer Become A Cancer?

Cause Of Fibroid Tumor

13. Synergies

Synergies. Continued

Heart weakness

Embolism

Nerve Connections

Inflammation

Suppuration

Purulent Foci

Chyliform Collections

Gangrene

Tubercles

Localization And Evolution Of Tuberculosis

B. Pathogeny

C. Pathological Physiology

D. Pathological Anatomy

E. Symptomatology

The Patient. Part 2

The Patient. Part 3

2. Appearance Of Patient

– Facial Expressions

– Skin

– Cerebral Derangements

– A Normal Person–Hunger

– An Abnormal Person-Appetite

3. Pain

– Relationship Of Pain To Other Facts Connected With Disease

– Pain Explained

4. Examination Of The Patient

(A) Organs Of Special Sense

(B) Vasomotor

(C) Heart

– Percussion

– The Normal Heart Sounds

– Disturbed Heart Rhythm

(D) Respiratory Apparatus

(E) Digestive Apparatus

– Flatulency

– Vomiting

– Stomach

– Intestine

– Fecal Matter

– Abdominal Pain And What It Signifies

– Abdominal Pain And What It Signifies. Continued

– Obscurity Of Abdominal Symptoms

– Volvulus (Twist In The Bowels)

– Liver

(F) Urinary Apparatus

– Chyluria

(G) Genital Organs

– Genital Organs. Continued

– Leucorrhea

– Abortion Habit

(H) The Nervous System

– Gait

– Convulsions

-Trembling Or Tremor

(F) Nosology

II. Diagnosis

III. Prognosis

IV. Therapeutics

Nature’s Plan as Concerns Utilization of Building Material

– Vitamin–What Is It?

– Vitamin–What Is It? Part 2

– Vitamin–What Is It? Part 3

– Vitamin–What Is It? Part 4

– Vitamin–What Is It? Part 5

– Vitamin–What Is It? Part 6

– Vitamin–What Is It? Part 7

– Vitamin–What Is It? Part 8

– Vitamin–What Is It? Part 9

– Vitamin–What Is It? Part10

– Vitamin–What Is It? Part11

Archaic Medicin

Con su teoría de la toxemia, John Tilden reconoció el papel del estrés en la causa de los problemas de salud mucho antes de que esto se convirtiera en una idea aceptada. Señaló que la salud se altera cuando la energía nerviosa se disipa y el cuerpo ya no es capaz de eliminar adecuadamente los subproductos tóxicos del metabolismo. El estado resultante de la auto-intoxicación, o toxemia, fue considerado por Tilden como causa básica única de deterioro de la salud. A su juicio, cada enfermedad es un esfuerzo de la naturaleza por eliminar la toxemia, o crisis de la toxemia. Según Tilden, la energía nerviosa podría convertirse en tóxica al consumir los alimentos equivocados, por comer en exceso, teniendo en cuenta también muchos estimulantes como el café y el alcohol, y también por otras fuentes de estrés, tales como tensiones emocionales y mentales. En 1910 comenzó a publicar una revista mensual llamada The Stuffed Club, que continuó hasta 1915 cuando cambió el nombre por el de Philosophy of Health, y que pasó a llamarse más tarde, en 1926, Health Review and Critique